Decrease in LDL-C is associated with decrease in all components of noncalcified plaque on coronary CTA

Autor: Piotr J. Slomka, Phi T. Huynh, Heidi Gransar, John D. Friedman, Balaji Tamarappoo, Yoav Arnson, Yuka Otaki, Daniel S. Berman, Sebastien Cadet, Mhairi Doris, Sean W. Hayes, Damini Dey, Louise Thomson, Frances Wang
Rok vydání: 2018
Předmět:
Zdroj: Atherosclerosis. 285
ISSN: 1879-1484
Popis: Background and aims LDL-C reduction has been associated with a decrease in noncalcified plaque (NCP) by serial quantitative coronary CT angiography (CTA). We evaluated the effect of LDL-C reduction on specific components of noncalcified plaque (NCP). Methods We analyzed 154 patients undergoing serial CTAs (118 men, 60 ± 10 years, interval 4 ± 2 years) with baseline LDL-C≥70 mg/dl. Semi-automated software was used for quantifying plaque components based on CT attenuation in Hounsfield units (HU): 30-75, low attenuation plaque (LAP); 76–130, medium-low attenuation plaque (MLAP); 131–350, medium attenuation plaque (MAP); >350, calcified plaque (CP). Decrease in LDL-C was defined as a reduction >10% of baseline LDL-C. Plaque volume changes were compared between patients with (n = 85) and without (n = 69) LDL-C decrease. Results There was interval reduction in total plaque, LAP, MLAP, and MAP volumes in patients with LDL-C decrease vs. patients without LDL-C decrease before and after adjusting for differences between the two groups (all p ≤ 0.001). An increase in CP volume occurred in both groups (p = 0.42). Conclusions Decrease in LDL-C was associated with reduction in all components of NCP measured by quantitative CTA. Change in total NCP volume may be the optimal measurement for assessing changes over time of coronary plaque on CTA.
Databáze: OpenAIRE
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