Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease
| Autor: | Anabel Chade, Cheryl Meng, Freya Kamel, Connie Marras, Marie Richards, Meike Kasten, David M. Umbach, Monica Korell, Caroline M. Tanner, G. Webster Ross, J. William Langston, Jane A. Hoppin, Melissa Furlong, Grace S. Bhudhikanok, Kathleen Comyns, Samuel M. Goldman, Dale P. Sandler, Aaron Blair |
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| Rok vydání: | 2015 |
| Předmět: |
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Aging Parkinson's disease Rural Health Neurodegenerative Occupational safety and health Toxicology Habits chemistry.chemical_compound Paraquat Hygiene Surveys and Questionnaires Personal protective equipment 80 and over Medicine Workplace lcsh:Environmental sciences General Environmental Science media_common Aged 80 and over lcsh:GE1-350 Neurodegenerative diseases Parkinson Disease Agriculture Middle Aged Neurological Female medicine.drug Risk Adult media_common.quotation_subject Gloves Article Rotenone Occupational Exposure Environmental health North Carolina Humans Pesticides Movement disorders Permethrin Occupational Health Aged business.industry Neurosciences Case-control study Pesticide equipment and supplies medicine.disease Iowa Trifluralin Brain Disorders Protective chemistry Case-Control Studies Gloves Protective business Environmental Sciences |
| Zdroj: | Environment International, Vol 75, Iss, Pp 144-150 (2015) |
| ISSN: | 0160-4120 |
| Popis: | Pesticides have been associated with Parkinson's disease (PD), and protective gloves and workplace hygiene can reduce pesticide exposure. We assessed whether use of gloves and workplace hygiene modified associations between pesticides and PD. The Farming and Movement Evaluation (FAME) study is a nested case–control study within the Agricultural Health Study. Use of protective gloves, other PPE, and hygiene practices were determined by questionnaire (69 cases and 237 controls were included). We considered interactions of gloves and hygiene with ever-use of pesticides for all pesticides with ≥5 exposed and unexposed cases and controls in each glove-use stratum (paraquat, permethrin, rotenone, and trifluralin). 61% of respondents consistently used protective gloves and 87% consistently used ≥2 hygiene practices. Protective glove use modified the associations of paraquat and permethrin with PD: neither pesticide was associated with PD among protective glove users, while both pesticides were associated with PD among non-users (paraquat OR 3.9 [95% CI 1.3, 11.7], interaction p = 0.15; permethrin OR 4.3 [95% CI 1.2, 15.6] interaction p = 0.05). Rotenone was associated with PD regardless of glove use. Trifluralin was associated with PD among participants who used |
| Databáze: | OpenAIRE |
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