The potential protective effect of the Polygonum hydropiper L against the development of fructose-induced oxidative stress and metabolic disorders in male Sprague-Dawely rats
| Autor: | Nasser Hadal Alotaibi, Muhammad Saleem, Muhammad Naveed Mushtaq, Khalid Saad Alharbi, Syed Nasir Abbas Bukhari, Amna Batool, Alamgeer |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Mean arterial pressure 030309 nutrition & dietetics Pharmaceutical Science Fructose 030204 cardiovascular system & hematology Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Metabolic Diseases medicine Animals Amlodipine Phenylephrine Flavonoids 0303 health sciences Plant Extracts Body Weight Polyphenols medicine.disease Rats Oxidative Stress Blood pressure chemistry Phytochemical Hypertension Polygonum Insulin Resistance Oxidative stress medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 74(4) |
| ISSN: | 2042-7158 |
| Popis: | Objectives Polygnum hydropiper L (Polygonaceae) is commonly known as smart weed. This study was designed to assess the effect of aqueous methanolic extract of P. hydropiper on oxidative stress and metabolic changes in fructose-induced hypertensive rats. Methods Male Sprague-Dawely rats were divided into six groups of five animals each (n = 5) and designated as normotensive group with distilled water, fructose-fed group with 10% fructose, standard control group with 10% fructose plus amlodipine (10 mg/kg) and treated groups with different doses of the aqueous methanolic extract of P. hydropiper (100, 200 and 400 mg/kg) plus 10% fructose daily for 6 weeks. Body weight gain was checked every week. Blood pressure parameters [systolic (SBP), diastolic (DBP), mean arterial pressure (MAP) and heart rate (HR)] and reactivity of extract with phenylephrine and adrenaline were measured by invasive method. Metabolic changes and oxidative stress parameters were measured from blood samples. Phytochemical analysis was also performed. Key findings Aqueous methanolic extract of P. hydropiper at 400 mg/kg decreased the blood pressure, heart rate, body weight and produced significant effect on metabolic and oxidative stress changes as compared to fructose-fed group. Phytochemical analysis revealed the presence of polyphenols and flavonoids in it. Conclusion The present results showed that aqueous methanolic extract of P. hydropiper possesses effect on oxidative stress and metabolic changes due to polyphenols and flavonoids. |
| Databáze: | OpenAIRE |
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