Expression of the luteinizing hormone receptor (LHR) in ovarian cancer
| Autor: | Alan L. Epstein, Rajesh K. Gaur, Paulette Mhawech-Fauceglia, Lynda D. Roman, Denice D. Tsao-Wei, Jacek Pinski, Shigang Xiong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Cancer Research Carcinoma Ovarian Epithelial lcsh:RC254-282 Andrology Surgical oncology Genetics Carcinoma Biomarkers Tumor Medicine Humans Stage (cooking) Receptor Aged Neoplasm Staging Aged 80 and over Ovarian Neoplasms Tissue microarray business.industry luteinizing hormone/choriogonadotropin receptor Middle Aged Receptors LH lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Staining Oncology Female Neoplasm Grading business Ovarian cancer Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019) |
| ISSN: | 1471-2407 |
| Popis: | We investigated the association of LHR expression in epithelial ovarian cancer (OC) with clinical and pathologic characteristics of patients. LHR expression was examined immunohistochemically using tissue microarrays (TMAs) of specimens from 232 OC patients. Each sample was scored quantitatively evaluating LHR staining intensity (LHR-I) and percentage of LHR (LHR-P) staining cells in tumor cells examined. LHR-I was assessed as no staining (negative), weak (+ 1), moderate (+ 2), and strong positive (+ 3). LHR-P was measured as 1 to 5, 6 to 50% and > 50% of the tumor cells examined. Positive LHR staining was found in 202 (87%) patients’ tumor specimens and 66% patients had strong intensity LHR expression. In 197 (85%) of patients, LHR-P was measured in > 50% of tumor cells. LHR-I was significantly associated with pathologic stage (p = 0.007). We found that 72% of stage III or IV patients expressed strong LHR-I in tumor cells. There were 87% of Silberberg’s grade 2 or 3 patients compared to 70% of grade 1 patients with LHR expression observed in > 50% of tumor cells, p = 0.037. Tumor stage was significantly associated with overall survival and recurrence free survival, p |
| Databáze: | OpenAIRE |
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