Relapsed or primary refractory AML

Autor: Alice S. Mims, Kristin L. Koenig
Rok vydání: 2020
Předmět:
Zdroj: Current Opinion in Hematology
ISSN: 1065-6251
Popis: Acute myeloid leukemia (AML) is a biologically heterogeneous disease of the hematopoietic system characterized by clonal accumulation and expansion of immature myeloid cells in the bone marrow. Unfortunately, with current treatment strategies, only approximately 35–40% of patients at least 60 years and 5–15% of patients older than 60 years are cured of this disease [1]. Even with adaptation of cytogenetic and molecular risk-stratified therapies, 10–40% of patients do not achieve a complete remission (CR) after intensive induction therapy and are deemed to have primary refractory disease. Refractory disease is defined by the European LeukemiaNet (ELN) as the inability to attain CR or complete remission with incomplete hematologic recovery (CRi) after two courses of intensive induction treatment. Of note, this definition is not consistent throughout the literature [2]. Although some patients are able to achieve CR, greater than 50% of these patients subsequently experience disease relapse [3]. For patients who relapse, only a small fraction undergo successful salvage treatment with ability to attain a second CR [3]. Additionally, these patients are often not candidates for aggressive treatment (i.e. allogeneic stem cell transplant [alloHSCT]) given comorbid conditions and lack of suitable donors. Therefore, this leaves a large unmet clinical need for treatment of both relapsed and refractory (R/R) AML. Open in a separate window Box 1 no caption available
Databáze: OpenAIRE
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