Magnetic fields exposure from high-voltage power lines and risk of amyotrophic lateral sclerosis in two Italian populations

Autor: Alessia Arena, Grazia Ghermandi, Daniela Sesti, P Zanichelli, Carlo Signorelli, Marco Vinceti, Vladimiro Pietrini, Silvia Violanti, Leeka Kheifets, Sara Fabbi, Federica Violi, Francesco Patti, Mario Zappia, Salvatore Sciacca, Nicola Fini, Margherita Ferrante, Cristina Mauceri, Anna Odone, A Dimartino, Elisa Arcolin, Caterina Ledda, Roberto Fava, S. Caldara, Carlotta Malagoli, Jessica Mandrioli, Tommaso Filippini, Paola Oleari, Maria Fiore, Laura Iacuzio, B Notari, Sergio Teggi, R. Calzolari, Maurizio Poli
Přispěvatelé: Vinceti, Marco, Malagoli, Carlotta, Fabbi, Sara, Kheifets, Leeka, Violi, Federica, Poli, Maurizio, Caldara, Salvatore, Sesti, Daniela, Violanti, Silvia, Zanichelli, Paolo, Notari, Barbara, Fava, Roberto, Arena, Alessia, Calzolari, Roberta, Filippini, Tommaso, Iacuzio, Laura, Arcolin, Elisa, Mandrioli, Jessica, Fini, Nicola, Odone, Anna, Signorelli, Carlo, Patti, Francesco, Zappia, Mario, Pietrini, Vladimiro, Oleari, Paola, Teggi, Sergio, Ghermandi, Grazia, Dimartino, Angela, Ledda, Caterina, Mauceri, Cristina, Sciacca, Salvatore, Fiore, Maria, Ferrante, Margherita
Rok vydání: 2017
Předmět:
Male
Amyotrophic lateral sclerosis
case-control study
electromagnetic fields
epidemiology
power lines
risk
Neurology
Neurology (clinical)
Pathology
Disease
0302 clinical medicine
Electricity
Risk Factors
Epidemiology
Prevalence
Medicine
030212 general & internal medicine
Unmeasured confounding
Aged
80 and over
education.field_of_study
Middle Aged
Radiation Exposure
power line
Italy
Female
High voltage power lines
medicine.medical_specialty
Population
Radiation Dosage
03 medical and health sciences
Age Distribution
electromagnetic field
Humans
Sex Distribution
Radiation Injuries
education
Amyotrophic lateral sclerosi
Aged
business.industry
Amyotrophic Lateral Sclerosis
Case-control study
Amyotrophic lateral sclerosis
electromagnetic fields
case-control study
epidemiology
risk
power lines
medicine.disease
Magnetic Fields
Etiology
business
030217 neurology & neurosurgery
Demography
Zdroj: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18:583-589
ISSN: 2167-9223
2167-8421
DOI: 10.1080/21678421.2017.1332078
Popis: The aetiology of amyotrophic lateral sclerosis (ALS), a rare and extremely severe neurodegenerative disease, has been associated with magnetic fields exposure. However, evidence for such a relation in the general population is weak, although the previous null results might also be due to exposure misclassification, or a relationship might exist only for selected subgroups. To test such a hypothesis we carried out a population-based case-control study in two Northern and Southern Italy regions, including 703 ALS cases newly diagnosed from 1998 to 2011 and 2737 controls randomly selected from the residents in the study provinces. Overall, we found that a residence near high-voltage power lines, within the corridors yielding a magnetic fields of ≥0.1 μT, was not associated with an excess disease risk, nor did we identify a dose-response relationship after splitting the exposed corridor according to the 0.1, 0.2 and 0.4 μT cut-points of exposure. These results were confirmed taking into account age at onset, period of diagnosis, sex, geographical area, and length of exposure. Overall, despite the residual possibility of unmeasured confounding or small susceptible subgroups not identified in our study, these results appear to confirm that the exposure to magnetic fields from power lines occurring in the general population is not associated with increased ALS risk.
Databáze: OpenAIRE
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