Rapid prototyping of scaphoid and lunate bones
| Autor: | Jason Lusk, Shaun D. Gittard, Pierre Morel, Filip Stockmans, Ramsey Michael D, Boris N. Chichkov, Aleksandr Ovsianikov, Claire Laverde, Jack Phillips, Roger J. Narayan, Nancy A. Monteiro-Riviere |
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| Rok vydání: | 2009 |
| Předmět: |
Keratinocytes
Rapid prototyping Materials science Compressive Strength Cell Survival Polymers medicine.medical_treatment Avascular necrosis Prosthesis Design Applied Microbiology and Biotechnology Prosthesis law.invention law Elastic Modulus Materials Testing parasitic diseases medicine Humans Lunate Bone Stereolithography Scaphoid Bone Analysis of Variance technology industry and agriculture Lunate bone Prostheses and Implants General Medicine medicine.disease Lunate Resins Synthetic Carpal bones medicine.anatomical_structure Computer-Aided Design Molecular Medicine Tomography X-Ray Computed Biomedical engineering Epidermal keratinocyte |
| Zdroj: | Biotechnology Journal. 4:129-134 |
| ISSN: | 1860-7314 1860-6768 |
| DOI: | 10.1002/biot.200800233 |
| Popis: | In this study, a novel rapid prototyping technology was used to fabricate scaphoid and lunate bone prostheses, two carpal bones that are prone to avascular necrosis. Carpal prostheses were fabricated with an Envisiontec Perfactory SXGA stereolithography system using Envisiontec eShell 200 photocurable polymer. Fabrication was guided using 3-D models, which were generated using Mimics software (Materialise NV, Leuven, Belgium) from patient computer tomography data. The prostheses were fabricated in a layer-by-layer manner; approximately 50-microm thick layers were observed in the prostheses. Hardness and Young's modulus values of polymerized eShell 200 material were 93.8 +/- 7.25 MPa and 3050 +/- 90 MPa, respectively. The minimum compressive force required for fracture was 1360 N for the scaphoid prosthesis and 1248 N for the lunate prosthesis. Polymerized Envisiontec eShell material exhibited high human neonatal epidermal keratinocyte cell viability rate in an MTT assay. The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use. |
| Databáze: | OpenAIRE |
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