Genetic Diversity of Human Metapneumovirus over 4 Consecutive Years in Australia
| Autor: | Emily McQueen, Theo P. Sloots, Michael D. Nissen, Katherine E. Arden, Seweryn Bialasiewicz, Ian M. Mackay, Kevin Jacob |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Adolescent Genes Viral Genotype viruses Molecular Sequence Data law.invention Human metapneumovirus law Genetic variation Humans Immunology and Allergy Child Respiratory Tract Infections Phylogeny Polymerase chain reaction Aged Aged 80 and over Molecular Epidemiology Genetic diversity Paramyxoviridae Infections biology Respiratory tract infections Molecular epidemiology Reverse Transcriptase Polymerase Chain Reaction Australia Infant Newborn Genetic Variation Infant virus diseases Sequence Analysis DNA Middle Aged biology.organism_classification Virology respiratory tract diseases Infectious Diseases Child Preschool RNA Viral Population study Female Metapneumovirus |
| Zdroj: | The Journal of Infectious Diseases. 193:1630-1633 |
| ISSN: | 1537-6613 0022-1899 2001-2004 |
| Popis: | The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001-2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. Concurrent, annual circulation of all 4 hMPV subtypes in our study population was common, with a single, usually different hMPV subtype predominating in each year. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|