Natural products improve healthspan in aged mice and rats: a systematic review and meta-analysis
| Autor: | Steffen Möller, Francesca Cirulli, Chiara Musillo, Walter Luyten, Alessandra Berry, Marta Borgi, Nadine Saul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gerontology
Aging Data call GINKGO-BILOBA Behavioral Neuroscience Mice 0302 clinical medicine WATER-MAZE DEFICITS Medicine OXIDATIVE STRESS LIFE-SPAN 0303 health sciences Cognition Dietary supplements Stress resistance 3. Good health ALZHEIMERS-DISEASE Neuropsychology and Physiological Psychology Meta-analysis Life Sciences & Biomedicine Behavioral Sciences Locomotion Cognitive Neuroscience Rat model Longevity 03 medical and health sciences Animal model Memory Healthy ageing Animals Physiological stress SPATIAL MEMORY 030304 developmental biology Biological Products Science & Technology business.industry Neurosciences PERFORMANCE COGNITIVE IMPAIRMENT Rats Ageing ageing animal model dietary supplements healthy ageing locomotion memory metabolism mice physiological stress rats Metabolism DENTATE GYRUS Neurosciences & Neurology business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience & Biobehavioral Reviews |
| Popis: | Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; "healthspan" is indeed the emerging concept of such quest for ageing without chronic or disabling diseases and dysfunctions. Regular consumption of natural products might improve healthspan, although the mechanisms of action are still poorly understood. Since preclinical studies aimed to assess the efficacy and safety of these compounds are growing, we performed a systematic review and meta-analysis on the effects of natural products on healthspan in mouse and rat models of physiological ageing. Results indicate that natural compounds show robust effects improving stress resistance and cognitive abilities. These promising data call for further studies investigating the underlying mechanisms in more depth. ispartof: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS vol:121 pages:89-105 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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