[3H]-GR113808 labels 5-HT4 receptors in the human and guinea-pig brain
| Autor: | Javoy-Agid F, Michèle Sebben, Joël Bockaert, Aline Dumuis, Grossman C, Christian Waeber |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Indoles Central nervous system Guinea Pigs Biology In Vitro Techniques Binding Competitive Guinea pig Radioligand Assay Internal medicine medicine Animals Humans Binding site Receptor Aged Aged 80 and over Brain Chemistry Sulfonamides Neocortex Membranes General Neuroscience Antagonist Receptor-mediated endocytosis Human brain medicine.anatomical_structure Endocrinology Biophysics Autoradiography Female Serotonin Antagonists |
| Zdroj: | Neuroreport. 4(11) |
| ISSN: | 0959-4965 |
| Popis: | A TRITIATED specific and highly potent 5-HT4 antagonist: [3H]-GR113808 was used to label specific binding sites in human brain and for comparison in guinea-pig brain. [3H]-GR113808 association and dissociation were rapid, the binding was saturable and displaced by various sero-toninergic agents with an affinity corresponding to their previously reported 5-HT4 receptor mediated effects. In vitro ligand binding autoradiography was used to investigate the distribution of [3H]-GR113808 recognition sites on human brain sections. The highest density was observed in the striato-nigral system. Low densities of binding sites were also found in hippocampus, neocortex and colliculus. This distribution of [3H]-GR113808 binding sites is similar to that found in the guinea-pig brain. |
| Databáze: | OpenAIRE |
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