Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men
| Autor: | Masayoshi Nakajima, Michio Tamatani, Shigeto Morimoto, Keisuke Fukuo, Toshio Ogihara, Tadaaki Niinobu, Toshio Onishi, Shoichi Kitano |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Vitamin K Bone density Endocrinology Diabetes and Metabolism Osteoporosis chemistry.chemical_compound Endocrinology Bone Density Internal medicine Vitamin D and neurology medicine Humans Testosterone Cyanoacrylates Vitamin D Aged Aged 80 and over Bone mineral Chemistry Vitamin K 2 Vitamin K 1 Middle Aged medicine.disease Osteopenia Bone Diseases Metabolic Ergocalciferol Cholecalciferol medicine.drug |
| Zdroj: | Metabolism. 47:195-199 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/s0026-0495(98)90220-7 |
| Popis: | Changes in the circulating factors participating in involutional osteoporosis have been intensively investigated in women, but little is known about this in men. We investigated the possible participation of circulating factors including testosterone, vitamin D metabolites, and vitamins K1 and K2 in osteopenia in elderly men. In a group of 27 ambulatory men aged 74 +/- 10 years (mean +/- SD; range, 60 to 90), the bone mineral density (BMD) of the second to fourth lumbar vertebrae was measured by dual-energy x-ray absorptiometry (DXA) and expressed as a Z score, the age-adjusted BMD value for the Japanese population (mean +/- SD, 0 +/- 1). Although the plasma level of total testosterone significantly decreased with age in the group, it did not significantly correlate with the Z score. However, the plasma levels of 25-hydroxyvitamin D (25-OHD), phylloquinone, menaquinone-7 (MK-7), and albumin were significantly positively correlated with the Z score. Moreover, plasma 25-OHD and both phylloquinone and MK-7 were significantly positively correlated in the subjects. These observations suggest that depressed circulating levels of 25-OHD and vitamin K concomitantly and cooperatively participate in osteopenia in elderly men, which may reflect the etiology of the type II moiety of involutional osteoporosis. |
| Databáze: | OpenAIRE |
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