Interaction of copper with titanium dioxide nanoparticles induced hematological and biochemical effects in Clarias gariepinus
| Autor: | Abalaka Samson Eneojo, Hussaina Mohammed Sanusi, Moise Matouke Matouke |
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| Rok vydání: | 2020 |
| Předmět: |
Clarias gariepinus
medicine.medical_specialty Health Toxicology and Mutagenesis Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Internal medicine Lactate dehydrogenase medicine Environmental Chemistry Metallothionein Animals Ecosystem Titanium biology General Medicine biology.organism_classification Pollution Oxidative Stress Endocrinology chemistry Liver Catalase Toxicity biology.protein Alkaline phosphatase Nanoparticles Copper Water Pollutants Chemical |
| Zdroj: | Environmental science and pollution research internationalReferences. 28(47) |
| ISSN: | 1614-7499 |
| Popis: | The increasing demand for engineered nanomaterials induces potential harmful impact into aquatic ecosystems and is a great concern for freshwater biodiversity. The present study showed that enhancing toxic property of titanium dioxide nanoparticles (TiO2 NPs) with copper (Cu) was responsible for the disruption of hormonal, hematological, and biochemical activities, in Clarias gariepinus. The study revealed that C. gariepinus intravenously injected with safe concentrations of TiO2 NPs (3μg g) and Cu (2.5 μg g) alone and binary mixtures (TiO2 NPs (3μg g) + Cu (2.5μg g)) for a period of 96h remarkably changed hormonal activities and hematological and biochemical indices of the fish. Our findings indicated that both chemicals accumulated in vital organs (the brain, serum, heart, gonad, liver, gills, serum, and kidney) and the presence of TiO2 NPs enhanced the bioavailability of copper. Fish exposed to TiO2 NPs alone significantly increased thyroxine (T4) and further decreased triidothyronine (T3). In addition, the binary mixtures showed antagonistic effects on both hormones. The hematological indices (WBC, RBC, HGt, MCV, MCH, MCHC, and Hct) were altered in all treatment groups. Decrease in WBC, RBC, HGt, Hct, and MCV were observed. Furthermore, the co-exposure further decreased WBC (60.28%), RBC (47.10%), HGt (75.99%), Hct (25.34%), and MCV (16.18%), in contrast, MCH and MCHC increased by of 2 folds, respectively. Metabolic enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) showed significant (p |
| Databáze: | OpenAIRE |
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