Axon formation, extension, and navigation: only a neuroscience phenomenon?
| Autor: | Jonathan R. Terman, Shannon K. Rich |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Computer science General Neuroscience Neurosciences Dendrite Cell Biology Neurotransmission Bristle Models Biological Axons Article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Extension (metaphysics) Biological Problem Phenomenon medicine Animals Axon Neuroscience Process (anatomy) 030217 neurology & neurosurgery |
| Zdroj: | Current opinion in neurobiology. 53 |
| ISSN: | 1873-6882 |
| Popis: | Understanding how neurons form, extend, and navigate their finger-like axonal and dendritic processes is crucial for developing therapeutics for the diseased and damaged brain. Although less well appreciated, many other types of cells also send out similar finger-like projections. Indeed, unlike neuronal specific phenomena such as synapse formation or synaptic transmission, an important issue for thought is that this critical long-standing question of how a cellular process like an axon or dendrite forms and extends is not primarily a neuroscience problem but a cell biological problem. In that case, the use of simple cellular processes — such as the bristle cell process of Drosophila — can aid in the fight to answer these critical questions. Specifically, determining how a model cellular process is generated can provide a framework for manipulations of all types of membranous process-containing cells, including different types of neurons. |
| Databáze: | OpenAIRE |
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