Sequence analysis of two de novo mutation alleles at the DXS10011 locus
| Autor: | Kiyoshi Matsui, Hajime Nishio, Koichi Suzuki, Akiyoshi Tamura, Izumi Takase, Misa Iwata, Tokiko Miyazaki |
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| Rok vydání: | 2003 |
| Předmět: |
Genetic Markers
Male Genetics Chromosomes Human X Daughter Genotype Sequence analysis media_common.quotation_subject De novo mutation Paternity Locus (genetics) Sequence Analysis DNA Biology Pathology and Forensic Medicine Issues ethics and legal aspects Tandem Repeat Sequences Genetic marker Mutation Humans Female Allele Alleles media_common |
| Zdroj: | Legal Medicine. 5:161-164 |
| ISSN: | 1344-6223 |
| DOI: | 10.1016/s1344-6223(03)00057-9 |
| Popis: | We have detected two unusual alleles at the DXS10011 locus in two paternity trio cases. In one case, one allele of the daughter was found not to have been derived from the mother but the other allele was shared with the father. In the other case, the mother and the son shared no bands. Paternity in both cases was established using conventional polymorphic markers in addition to DNA markers (probabilities: >0.999999). Sequencing showed that the two de novo alleles of the children acquired a single unit (GAAA). |
| Databáze: | OpenAIRE |
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