SDF-1/CXCR4 axis in myelodysplastic syndromes: Correlation with angiogenesis and apoptosis
| Autor: | Yaqin zhi, Yizhuo Zhang, Haifeng Zhao, Wanming Da, Xiaoxiong Wu, Wenrong Huang, Lu Sun, Dandan Zhao |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Receptors CXCR4 Cancer Research Angiogenesis Cell CD34 Apoptosis Enzyme-Linked Immunosorbent Assay CXCR4 Immunoenzyme Techniques Neovascularization Young Adult hemic and lymphatic diseases Humans Medicine Child Receptor Aged Neovascularization Pathologic business.industry Myelodysplastic syndromes Hematology Middle Aged Prognosis medicine.disease Chemokine CXCL12 medicine.anatomical_structure Oncology Case-Control Studies Myelodysplastic Syndromes Cancer research Female Neoplasm Grading medicine.symptom business |
| Zdroj: | Leukemia Research. 36:281-286 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2011.06.017 |
| Popis: | To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression on CD34+ cell than low-grade MDS and the control. It was suggested that the SDF-1/CXCR4 axis play an important role in MDS. Apoptosis was significantly increased in low-grade MDS, compared with high-grade MDS. The expression of VEGF and MVD were higher in the high-grade MDS than in the low-grade MDS. There are positive correlations between SDF-1 and apoptosis in the low-grade MDS. For the high-grade MDS, there were positive correlations between CXCR4 and VEGF, and between SDF-1 concentration and MVD. The apoptosis is one of the hallmarks for low-grade MDS and the angiogenesis for high-grade MDS. A refined understanding of the roles that SDF-1/CXCR4 axis and its correlation with angiogenesis and apoptosis play in MDS will fuel the development of therapies that can be targeted to the SDF-1/CXCR4 axis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect