Status of minimal residual disease after induction predicts outcome in both standard and high‐risk Ph‐negative adult acute lymphoblastic leukaemia : the Polish Adult Leukemia Group ALL 4‐2002 MRD Study
| Autor: | Beata Stella-Holowiecka, Wiesław Wiktor Jędrzejczak, Ilona Seferynska, Malgorzata Krawczyk-Kulis, Krzysztof Lewandowski, Agnieszka Balana-Nowak, Beata Piatkowska-Jakubas, Monika Paluszewska, Jerzy Holowiecki, Andrzej Lange, Marek Kielbinski, Krystyna Jagoda, Sebastian Giebel, Maria Król, Aleksander B. Skotnicki, Anna Czyż, Krzysztof Warzocha, Andrzej Hellmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Risk Oncology Pediatrics medicine.medical_specialty Neoplasm Residual Adolescent acute lymphoblastic leukaemia Bone Marrow Cells flow cytometry Immunophenotyping Young Adult Antigens CD Predictive Value of Tests Recurrence hemic and lymphatic diseases Acute lymphocytic leukemia Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Young adult Prospective cohort study Hematology business.industry Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Flow Cytometry Prognosis medicine.disease Minimal residual disease body regions Leukemia minimal residual disease Population study Female Poland business |
| Popis: | The treatment of adults with Philadelphia-negative acute lymphoblastic leukaemia (ALL) depends on the presence of risk factors including age, white blood cell count, immunophenotype and time to complete remission. In recent years, status of minimal residual disease (MRD) has been postulated as an additional risk criterion. This study prospectively evaluated the significance of MRD. Patients were treated with a uniform Polish Adult Leukemia Group (PALG) 4-2002 protocol. MRD status was assessed after induction and consolidation by multiparametric flow cytometry. Out of 132 patients included (age, 17-60 years), 116 patients were suitable for analysis. MRD level >/=0.1% of bone marrow cells after induction was found to be a strong and independent predictor for relapse in the whole study population (P < 0.0001), as well as in the standard risk (SR, P = 0.0003) and high-risk (P = 0.008) groups. The impact of MRD after consolidation on outcome was not significant. The combination of MRD status with conventional risk stratification system identified a subgroup of patients allocated to the SR group with MRD |
| Databáze: | OpenAIRE |
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