Rapid and early α-fetoprotein and des-γ-carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma
| Autor: | Kinya Okamoto, Keiko Hosho, Masahiko Koda, Manabu Kishina, Takaaki Sugihara, Jun-ichi Okano, Shiho Tokunaga, Tomomitsu Matono, Toshiaki Okamoto, Masanori Hodotsuka, Yoshikazu Murawaki, Kenji Oyama, Yuki Fujise, Kenichi Miyoshi |
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| Rok vydání: | 2015 |
| Předmět: |
Cisplatin
Cancer Research medicine.medical_specialty Pathology Chemotherapy business.industry medicine.medical_treatment Mitomycin C Cancer Articles medicine.disease Gastroenterology Molecular medicine digestive system diseases Oncology Internal medicine Hepatocellular carcinoma medicine business Progressive disease medicine.drug Epirubicin |
| Zdroj: | Molecular and Clinical Oncology. 3:655-662 |
| ISSN: | 2049-9469 2049-9450 |
| Popis: | The aim of the present study was to predict the effects of transarterial infusion (TAI) chemotherapy based on early changes in α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) in patients with advanced hepatocellular carcinoma (HCC). Seventy-four patients who underwent TAI with cisplatin, 5-fluorouracil, mitomycin C and epirubicin for advanced HCC were enrolled. Antitumor responses were evaluated 6 months after TAI. Rapid and early responses were defined as the ratio of AFP or DCP after 1 week and 1 month compared to baseline. A total of 5, 10, 17 and 42 patients had complete response (CR), partial response (PR), stable disease (SD) or progressive disease (PD), respectively. Early AFP response was significantly lower in the CR+PR compared to the SD+PD groups (P |
| Databáze: | OpenAIRE |
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