Effect of dibutyltin on placental and fetal toxicity in rat
| Autor: | Seigo Hayashi, Satoshi Furukawa, Yoshikazu Yamagishi, Chisato Hayakawa, Yoshiyuki Kobayashi, Yusuke Kuroda, Masayuki Kimura, Akihiko Sugiyama, Naho Tsuji, Masayoshi Abe |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Fetal Resorption Placenta Administration Oral Apoptosis Gestational Age 010501 environmental sciences Toxicology 01 natural sciences Facial Bones Andrology 03 medical and health sciences Pregnancy medicine Organotin Compounds Conceptus Animals Tissue Distribution Yolk sac Rats Wistar Maternal-Fetal Exchange 0105 earth and related environmental sciences Fetus Fetal Growth Retardation Chemistry Skull Allantois Embryo Organ Size Chorioallantoic membrane 030104 developmental biology medicine.anatomical_structure Fetal Weight embryonic structures Fetal Mortality Female |
| Zdroj: | The Journal of toxicological sciences. 42(6) |
| ISSN: | 1880-3989 |
| Popis: | In order to elucidate the effect of chorioallantoic and yolk sac placenta on the embryonic/fetal toxicity in dibutyltin dichloride (DBTCl)-exposed rats, we examined the histopathological changes and the tissue distribution of dibutyltin in the placentas and embryos. DBTCl was orally administered to the groups at doses of 0 mg/kg during gestation days (GD)s 7-9 (control group) and 20 mg/kg during GDs 7-9 (GD7-9 treated group), and GDs 10-12 (GD10-12 treated group). The total fetal mortality was increased, and malformations characterized by craniofacial dysmorphism were detected in the GD7-9 treated group. The embryonic/fetal weight and placental weight showed a decrease in both DBTCl-treated groups. Histologically, some embryos on GD 9.5 in the GD7-9 treated group underwent apoptosis without any changes of yolk sac. In the laser ablation-inductively coupled plasma-mass spectrometry analysis (LA-ICP-MS), tin was detected in the embryo, allantois, yolk sac, ectoplacental cone and decidual mass surrounding the conceptus on GD 9.5 in the GD7-9 treated group. Thus, it is considered that the embryo in this period is specifically sensitive to DBTCl-induced apoptosis, compared with other parts. The chorioallantoic placentas in both DBTCl-treated groups showed the developmental delay and hypoplasia in the fetal parts of placenta, resulting from apoptosis and mitotic inhibition. Thus, it was speculated that the DBTCl-induced malformations and fetal resorption resulted from the apoptosis in the embryo caused by the direct effect of DBTCl. The DBTCl-induced lesions in the chorioallantoic placenta were a non-specific transient developmental retardation in the fetal parts of placenta, leading to intrauterine growth retardation. |
| Databáze: | OpenAIRE |
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