Early time points perfusion imaging
| Autor: | Thomas Benner, David A. Chesler, Suk-Tak Chan, Koen Nelissen, Kenneth K. Kwong, Ona Wu, Joseph B. Mandeville, Wim Vanduffel, Timothy G. Reese, Mary M. Foley |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Gadolinium DTPA
Computer science Cognitive Neuroscience Models Neurological Perfusion scanning Brain mapping Article medicine Animals Computer vision Brain Mapping medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Magnetic Resonance Imaging Neurology Cerebral blood flow Cerebrovascular Circulation Artificial intelligence Radiopharmaceuticals Mr images Nuclear medicine business Monte Carlo Method |
| Zdroj: | NeuroImage. 54:1070-1082 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2010.09.011 |
| Popis: | The aim was to investigate the feasibility of making relative cerebral blood flow (rCBF) maps from MR images acquired with short TR by measuring the initial arrival amount of Gd-DTPA evaluated within a time window before any contrast agent has a chance to leave the tissue. We named this rCBF measurement technique utilizing the early data points of the Gd-DTPA bolus the “early time points” method (ET), based on the hypothesis that early time point signals were proportional to rCBF. Simulation data were used successfully to examine the ideal behavior of ET while monkey's MRI results offered encouraging support to the utility of ET for rCBF calculation. A better brain coverage for ET could be obtained by applying the Simultaneous Echo Refocusing (SER) EPI technique. A recipe to run ET was presented, with attention paid to the noise problem around the time of arrival (TOA) of the contrast agent. |
| Databáze: | OpenAIRE |
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