Chemokine and Cytokine Profiles in Patients with Hand Osteoarthritis
| Autor: | Karel Pavelka, Jiří Vencovský, Michal Tomcik, Hana Hulejová, J. Baloun, Ladislav Šenolt, O. Sleglova, Jindřiška Gatterová, Olga Růžičková, Tereza Kropáčková |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Eotaxin Chemokine CCL11 Male hand osteoarthritis erosive disease cytokines chemokines medicine.medical_specialty Chemokine Necrosis medicine.medical_treatment lcsh:QR1-502 Inflammation Physical examination chemokines Biochemistry Gastroenterology Article lcsh:Microbiology Pathogenesis 03 medical and health sciences 0302 clinical medicine erosive disease Internal medicine Osteoarthritis medicine Humans Molecular Biology Chemokine CCL2 Aged 030203 arthritis & rheumatology hand osteoarthritis medicine.diagnostic_test biology business.industry Tumor Necrosis Factor-alpha Interleukin-8 Middle Aged Hand cytokines 030104 developmental biology Cytokine biology.protein Disease Progression Female medicine.symptom business Hand osteoarthritis |
| Zdroj: | Biomolecules, Vol 11, Iss 4, p 4 (2021) Biomolecules Volume 11 Issue 1 |
| Popis: | Background: The development of hand osteoarthritis (HOA) and its progression into the erosive subset are unclear, but inflammation is suspected to be the main source. To verify the involvement of inflammation in HOA pathogenesis, we evaluate serum inflammatory mediators and their association with HOA-related clinical features in patients. Methods: 153 participants (50 non-erosive HOA patients, 54 erosive HOA patients, and 49 healthy control subjects) were included in this study. All patients underwent clinical examination, which included assessment of tender and swollen small hand joints, ultrasound (US) examination, and self-reported measures (e.g., AUSCAN or algofunctional indexes). Serum inflammatory mediators were quantified using human cytokine 27-plex immunoassay. We employed linear modelling, correlation analysis, and resampling statistics to evaluate the association of these mediators to HOA. Results: We identified increased levels of nine inflammatory mediators (e.g., eotaxin, monocyte chemoattractant protein 1, interleukin-8, and tumour necrosis factor) in HOA patients compared to healthy controls. Increased mediators correlated with ultrasound findings as well as with clinically tender and swollen joint counts in patients with erosive HOA. However, none of the mediators distinguished between erosive and non-erosive HOA subtypes. Conclusion: Our findings support the hypothesis on the involvement of inflammation in HOA. |
| Databáze: | OpenAIRE |
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