Hypertension and renal outcomes in normotensive kidney donors with multiple renal arteries
| Autor: | Duc T. Nguyen, Nisarg V. Gandhi, Edward A. Graviss, Dina N. Murad, Hassan N. Ibrahim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Renal function Kidney Nephrectomy Renal Artery Internal medicine medicine.artery Living Donors Humans Medicine cardiovascular diseases Family history Renal artery Kidney transplantation Retrospective Studies Transplantation Proteinuria business.industry medicine.disease Kidney Transplantation eye diseases medicine.anatomical_structure Hypertension Propensity score matching Cardiology medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Transplant International. 34 |
| ISSN: | 0934-0874 1432-2277 |
| DOI: | 10.1111/tri.14024 |
| Popis: | Having multiple renal arteries (MRA) has been linked to hypertension development. Whether kidney donors who are left with MRA in the nondonated kidney incur a higher risk of hypertension has not been studied. We compared the development of hypertension, reduced estimated glomerular filtration rate (eGFR), cardiovascular disease, and mortality in 2624 normotensive kidney donors with MRA in the nondonated kidney and to 2624 propensity score matched normotensive donor controls with a single renal artery. In total, 35% of donors had MRA. Donors with MRA were less likely to have undergone a left nephrectomy (51% vs. 83%). Postdonation hypertension was associated with age, male gender, non-White ethnicity, obesity, and family history of hypertension. Having MRA was not associated with risk of hypertension; aHR 0.92 (95% CI 0.82-1.03), P = 0.16. After 17 ± 11 years from donation, a similar proportion of donors with and without MRA developed cardiovascular disease, proteinuria and eGFR |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text