Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease
| Autor: | Nicholas S Hopkinson, Sahar Mourad, Andrew J. Montgomery, Michael I. Polkey, Ahmed S Sadaka |
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| Rok vydání: | 2018 |
| Předmět: |
Male
PREDICTOR Time Factors Respiratory System Kaplan-Meier Estimate 6-MIN WALK TEST Severity of Illness Index DESATURATION Hypoxemia AIR-FLOW OBSTRUCTION Pulmonary Disease Chronic Obstructive 0302 clinical medicine PULMONARY-DISEASE 030212 general & internal medicine Hypoxia Lung Original Research RISK COPD Exercise Tolerance exercise General Medicine Middle Aged Obstructive lung disease Treatment Outcome medicine.anatomical_structure Ambulatory Cardiology Female medicine.symptom Life Sciences & Biomedicine NUTRITIONAL-STATUS medicine.medical_specialty Walk Test International Journal of Chronic Obstructive Pulmonary Disease 1102 Cardiovascular Medicine And Haematology 03 medical and health sciences Internal medicine COPD PATIENTS medicine Humans obstructive lung disease Exertion Aged Proportional Hazards Models Retrospective Studies Science & Technology hypoxemia business.industry MORTALITY Oxygen Inhalation Therapy Recovery of Function Hypoxia (medical) 6-minute walking test medicine.disease Logistic Models 030228 respiratory system DISTANCE Multivariate Analysis business oxygen Body mass index |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| Popis: | Ahmed S Sadaka,1,3 Andrew J Montgomery,2 Sahar M Mourad,3 Michael I Polkey,1 Nicholas S Hopkinson1 1NIHR Respiratory Biomedical Research Unit at the Royal Brompton Hospital and Imperial College, Respiratory Medicine, London, UK; 2Royal Brompton and Harefield NHS Foundation Trust, London, UK; 3Alexandria University Faculty of Medicine, Chest Department, Alexandria, Egypt Purpose: Hypoxemia is associated with more severe lung disease and worse outcomes. In some patients with chronic obstructive lung diseases who desaturate on exertion, supplemental oxygen improves exercise capacity. The clinical significance of this exercise response to oxygen supplementation is not known.Patients and methods: We identified chronic obstructive lung disease patients at our center who underwent a 6-minute walking test (6MWT) for ambulatory oxygen assessment and who desaturated breathing air and therefore had an additional walk test on supplemental oxygen, between August 2006 and June 2016. Responders were defined as walking ≥26 m further with oxygen. Survival was determined up to February 1, 2017. We compared survival in oxygen responders and nonresponders in patients with obstructive lung diseases.Results: One hundred and seventy-four patients were included in the study, median age 70 years. Seventy-seven (44.3%) of the patients were oxygen responders. Borg dyspnea score improved by 1.4 (±1.4) units (P |
| Databáze: | OpenAIRE |
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