BONE METABOLISM AND MINERALIZATION AFTER CYTOTOXIC CHEMOTHERAPY INCLUDING IFOSFAMIDE
| Autor: | Jacques Otten, Said Hachimi-Idrissi, R. Maurus, Olivia Louis, J. De Schepper |
|---|---|
| Přispěvatelé: | Supporting clinical sciences, Research Group Critical Care and Cerebral Resuscitation, Vriendenkring VUB |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Adolescent Bone density Bone disease Parathyroid hormone Bone and Bones Bone remodeling Bone Density Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Hypercalciuria Ifosfamide Child Bone mineral Lumbar Vertebrae business.industry Phosphorus medicine.disease Osteopenia Bone Diseases Metabolic Endocrinology Child Preschool Pediatrics Perinatology and Child Health Alkaline phosphatase Calcium Female business Research Article |
| Popis: | Lumbar spine bone mineral density and bone mineral metabolism were studied in 13 children three months or more after completion of cytotoxic chemotherapy that included ifosfamide given for different malignancies. Blood and urine were analysed for calcium, phosphorus, and magnesium and blood for alkaline phosphatase activity, parathyroid hormone, and 1,25(OH)2 vitamin D3. Bone mineral density (BMD) was measured at the lumbar spine (L1-L4) using a commercial dual x ray absorptiometer. Serum concentrations of calcium, phosphorus, and magnesium and alkaline phosphatase activity, as well as plasma 1,25(OH)2 vitamin D3 concentrations were normal in all children. Slightly raised parathyroid hormone concentrations were seen in two children. An increased urinary excretion of calcium was found in five children. Mean (SD) BMD of the children was -0.88 (1.44). Three children had osteopenia, as defined by a BMD lower than -2 SD for age and sex related standards. No significant relation was found between the BMD and the biochemical parameters. In conclusion, a normal BMD was found in most patients who had received ifosfamide, even in those with persisting hypercalciuria. |
| Databáze: | OpenAIRE |
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