Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats
| Autor: | Uma Maheswari Krishnan, Arunachalam Muthuraman, Nirmal Singh, Palanichamy Shanmugam, Venkata Rathina Kumar Thiagarajan |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Tail Hot Temperature Health Toxicology and Mutagenesis Pregabalin Pharmacology Toxicology Thiobarbituric Acid Reactive Substances Antioxidants Butea medicine Animals Rats Wistar gamma-Aminobutyric Acid Pain Measurement Analgesics Dysesthesia Behavior Animal biology Plant Extracts business.industry Public Health Environmental and Occupational Health Peripheral Nervous System Diseases biology.organism_classification Antineoplastic Agents Phytogenic Glutathione Sciatic Nerve Hindlimb Rats Plant Leaves Disease Models Animal Oxidative Stress Treatment Outcome Allodynia Nociception Hyperalgesia Vincristine Neuropathic pain Neuralgia Calcium Female Sciatic nerve medicine.symptom business medicine.drug |
| Zdroj: | Toxicology and Industrial Health. 29:3-13 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233711432573 |
| Popis: | Neuropathic pain is a chronic neurodegenerative disease. It is well characterized by spontaneous pain, hyperalgesia, hypothesia, dysesthesia and allodynia. The present study was designed to investigate the antinociceptive potential of Butea monosperma on vincristine-induced painful neuropathy in rats. Vincristine was administered for induction of neuropathic pain in experimental animals. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia and allodynia in the hind paw and tail thermal hyperalgesia, respectively, as an index of peripheral and central pain sensation. Tissue thiobarbituric acid reactive substances (TBARSs), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Microscopically, histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of B. monosperma leaves and pregabalin were administered for 14 consecutive days. Vincristine administration resulted in significant reduction in behavioural (i.e. hyperalgesia and allodynic pain sensation) changes along with a rise in the levels of TBARS, total calcium and decrease in GSH levels when compared with the normal control group. Moreover, significant histological changes were also observed. Pretreatment with B. monosperma significantly attenuated vincristine-induced development of painful behavioural, biochemical and histological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. B. monosperma ameliorated vincristine-induced painful neuropathy. It may be due to its potential of antioxidative, neuroprotective and calcium channel inactivation. |
| Databáze: | OpenAIRE |
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