Pyridinium crosslinks as markers of bone resorption in patients with breast cancer
| Autor: | SP Robins, PE Preece, J M Horobin, Alfred Cuschieri, CR Paterson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Deoxypyridinoline Urinary system Mammary gland Urology Bone Neoplasms Breast Neoplasms Pilot Projects Pyridinium Compounds macromolecular substances Bone resorption Metastasis chemistry.chemical_compound Breast cancer Humans Medicine Amino Acids Bone Resorption Aged Pyridinoline business.industry technology industry and agriculture Middle Aged medicine.disease Resorption Cross-Linking Reagents medicine.anatomical_structure Oncology chemistry Calcium Female Collagen business Biomarkers Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1991.419 |
| Popis: | Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastases in bone or elsewhere after 1 year's subsequent follow up. Eight out of the ten patients with metastases had crosslink excretion values higher than the reference interval, but so did some patients without known metastatic disease. For both crosslinks there was a clear correlation with serum alkaline phosphatase activity measured at about the same time. We consider that measurement of urinary collagen crosslink assays may have a place in the early detection of metastatic spread to bone. |
| Databáze: | OpenAIRE |
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