Age-Related Changes in Gastric Mucosal Repair and Proliferative Activities in Rats Exposed Acutely to Aspirin
| Autor: | Makau Lee, W. E. Hardman, I. Cameron |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Senescence Aging Pathology medicine.medical_specialty Time Factors Lesion medicine Gastric mucosa Animals Regeneration Wound Healing Aspirin biology Stomach Regeneration (biology) Anti-Inflammatory Agents Non-Steroidal digestive oral and skin physiology Rats Inbred F344 digestive system diseases Rats Proliferating cell nuclear antigen medicine.anatomical_structure Gastric Mucosa biology.protein Geriatrics and Gerontology medicine.symptom Wound healing Cell Division medicine.drug |
| Zdroj: | Gerontology. 44:198-203 |
| ISSN: | 1423-0003 0304-324X |
| DOI: | 10.1159/000022010 |
| Popis: | The present study was designed to determine whether there are any age-related changes in the repair of acute gastric mucosal injury induced by aspirin in Fischer 344 rats. We have also examined the influence of aging on gastric mucosal proliferative activities, a major component of gastric mucosal defense and repair mechanisms. Our data demonstrated that aging was associated with significant delays in both resolution of gross mucosal injury and regeneration of the injured gastric mucosa. However, there were no correlations between the regeneration of the injured gastric mucosa and gastric mucosal expression of proliferating cell nuclear antigen and transforming growth factor-α immunoreactivities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|