Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs
| Autor: | Gabriela Borilova, Nguyen Xuan Hoa, Guangzhi Zhang, Jan A.M. Langermans, Dennis L. Foss, Hiroyoshi Ota, Han Liu, Jay V. Solnick, Sara K. Lindén, Maria Pia Franciosini, Aizhen Guo, O. O. Omotosho, Bram Flahou, Patrizia Casagrande Proietti, Frank Pasmans, Masahiko Nakamura, Jukka Corander, Sofie De Bruyckere, Anders Øverby, Mirko Rossi, Takehisa Matsumoto, Jaco Bakker, Chloë De Witte, Annemieke Smet, Miriam E. Martin, Hidenori Matsui, Freddy Haesebrouck, Edwin Heuvelman, Jani O'Rourke, Richard Ducatelle, Ana Paula Frederico Rodrigues Loureiro Bracarense, Le Duc Ngoan, Laurice A. Kopta |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Technology Swine Evolution Population Helicobacter heilmannii Zoology Microbiology Helicobacter Infections 03 medical and health sciences Behavior and Systematics Phylogenetics biology.animal medicine Animals Humans Primate Domestication education Pathogen Domestic Biology Ecology Evolution Behavior and Systematics Phylogeny Swine Diseases education.field_of_study biology Ecology Host (biology) Stomach Helicobacter pylori Biological Sciences biology.organism_classification Virology Macaca mulatta Macaca fascicularis Chemistry 030104 developmental biology medicine.anatomical_structure Infectious Diseases Emerging Infectious Diseases Animals Domestic Original Article Human medicine Digestive Diseases Infection Environmental Sciences |
| Zdroj: | The ISME journal : multidisciplinary journal of microbial ecology The ISME journal, vol 12, iss 1 |
| ISSN: | 1751-7362 |
| Popis: | Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans |
| Databáze: | OpenAIRE |
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