Regions of the Lipopolysaccharide of Pseudomonas aeruginosa Essential for Antitumor and Interferon-Inducing Activities
| Autor: | Yasuhiko Kojima, Chiyoji Abe, Ken-ichi Tanamoto, J. Yuzuru Homma |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Lipopolysaccharides
Interferon Inducers Lipopolysaccharide Proteolipids Carbohydrates Antineoplastic Agents Biology Hydroxylamines medicine.disease_cause Polysaccharide Biochemistry Microbiology Lipid A Mice Structure-Activity Relationship chemistry.chemical_compound Interferon Ascites medicine Animals Amino Acids chemistry.chemical_classification Pseudomonas aeruginosa Chemical modification In vitro Hydrazines chemistry Female Interferons Lymph Nodes Rabbits medicine.symptom Spleen medicine.drug |
| Zdroj: | European Journal of Biochemistry. 97:623-629 |
| ISSN: | 1432-1033 0014-2956 |
| Popis: | Resistance against ascites tumor development and interferon-inducing activity were demonstrated in lipopolysaccharide derived from the protein-lipopolysaccharide complex obtained from an autolysate of Pseudomonas aeruginosa. Lipid A obtained from the lipopolysaccharide was sufficient to induce interferon in vitro but no antitumor activity was found if lipid A or the polysaccharide derived from lipopolysaccharide was injected into the animal. Chemical modification of the polysaccharide portion or deacylation of the lipopolysaccharide also diminished antitumor activity. In contrast, interferon was induced by these incomplete lipopolysaccharides. These results indicate that both the lipid A portion and covalently linked polysaccharide are necessary for the inhibition of ascites tumor development, whereas incomplete lipid A with amide-linked fatty acids is sufficient to induce interferon in vitro. |
| Databáze: | OpenAIRE |
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