Antifungal Activity fromAlpinia galangaand the Competition for Incorporation of Unsaturated Fatty Acids in Cell Growth
| Autor: | Miyoko Nagao, Hiroyuki Haraguchi, Yoshiharu Kuwata, Kozo Inada, Kazumoto Miyahara, Akira Yagi, Kazushi Shingu |
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| Rok vydání: | 1996 |
| Předmět: |
Chalcone
Antifungal Agents food.ingredient Membrane permeability Alpinia galanga Pharmaceutical Science Microbial Sensitivity Tests Fatty Acids Nonesterified Naphthalenes Analytical Chemistry chemistry.chemical_compound food Candida albicans Drug Discovery Spiro Compounds Asia Southeastern Pharmacology Plants Medicinal Bacteria biology Organic Chemistry Fungi Biological activity biology.organism_classification Antimicrobial Corpus albicans Complementary and alternative medicine chemistry Biochemistry Molecular Medicine Medicine Traditional Diterpenes Diterpene |
| Zdroj: | Planta Medica. 62:308-313 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2006-957890 |
| Popis: | An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8 beta, 17-epoxylabd-12-ene-15, 16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin and chalcone against Candida albicans. Antifungal activity of 1 was reversed by unsaturated fatty acids. Protoplasts of C. albicans were lysed by 1. These results suggest that antifungal activity of 1 is due to a change of membrane permeability arising from membrane lipid alternation. |
| Databáze: | OpenAIRE |
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