Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety
| Autor: | Brenda W.J.H. Penninx, Nils Kappelmann, Gerard van Grootheest, Shenghua Zong, Peter C. M. Molenaar, Carolin Correia-Hoffmann, Pilar Martinez-Martinez, Rob P.W. Rouhl, Mario Losen, Marina Mané-Damas |
|---|---|
| Přispěvatelé: | Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Digital Health, Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R2 - Mental Health, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
DISORDER
medicine.medical_specialty Hashimoto Disease Anxiety Receptor antibodies Molecular neuroscience Gastroenterology Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine SCHIZOPHRENIA medicine Disorder Animals Humans Hippocampus (mythology) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Depression (differential diagnoses) Prevalence Autoantibodies Autoimmune encephalitis Depression business.industry ENCEPHALITIS Autoantibody medicine.disease RECEPTOR ANTIBODIES Rats 030227 psychiatry PREVALENCE Psychiatry and Mental health Schizophrenia Immunohistochemistry Encephalitis medicine.symptom Psychiatric disorders business 030217 neurology & neurosurgery |
| Zdroj: | Translational Psychiatry, 10(1):404. Nature Publishing Group Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020) Zong, S, Correia-Hoffmann, C, Mané-Damas, M, Kappelmann, N, Molenaar, P C, van Grootheest, G, Penninx, B W J H, Rouhl, R P W, Losen, M & Martinez-Martinez, P 2020, ' Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety ', Translational Psychiatry, vol. 10, no. 1, 404 . https://doi.org/10.1038/s41398-020-01083-y Translational Psychiatry |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-020-01083-y |
| Popis: | Neuronal surface autoantibodies (NSAbs) against various antigens cause autoimmune encephalitis. Some of these antigens are also involved in the pathology of depression and anxiety. To study whether NSAbs are more common in plasma of individuals with depression and anxiety than in controls, and to investigate if NSAbs correlate with disease status, plasma samples of 819 individuals with a current diagnosis of depression and/or anxiety, 920 in remission and 492 individuals without these disorders were included in this study. Samples were tested by a combination of immunohistochemistry (IHC), staining on live rat hippocampus neurons and cell-based assay (CBA). By IHC, 50 (2.2%) samples showed immunoreactivity to rat brain tissue, with no significant differences between the aforementioned groups (22/819 vs 18/920 vs 11/492, P > 0.99). In addition, eight IHC positive samples were positive for NSAbs on live neurons (7/819 vs 0/920 vs 1/492, P = 0.006). The IHC-staining patterns of these eight samples were atypical for autoimmune encephalitis and accordingly, they tested negative for known NSAbs by CBA. No obvious difference in the clinical characteristics between individuals with or without NSAbs was observed. In conclusion, novel NSAbs were rare but predominately found in patients with current anxiety or depression indicating they might affect mental health in a small group of patients. |
| Databáze: | OpenAIRE |
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