Morphometric and Immunohistochemical Characterization of Bladder Carcinoma in situ and Its Preneoplastic Lesions
| Autor: | M. C. Sanchez-Fernandez De Sevilla, L Morell-Quadreny, M. Perez-Bacete, Antonio Llombart-Bosch, Manuel Gil-Salom |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Isoantigens Pathology medicine.medical_specialty Urology Nuclear area urologic and male genital diseases Epithelium Antigen Lectins Carcinoma Humans Medicine Urothelium Aged Cell Nucleus biology business.industry Carcinoma in situ Middle Aged medicine.disease Antigens Differentiation Immunohistochemistry female genital diseases and pregnancy complications Urinary Bladder Neoplasms biology.protein Female Antibody business Precancerous Conditions Carcinoma in Situ |
| Zdroj: | European Urology. 21:5-9 |
| ISSN: | 1873-7560 0302-2838 |
| DOI: | 10.1159/000474878 |
| Popis: | We performed a morphometric and immunohistochemical study of 26 bladder carcinoma in situ (Cis) specimens, compared with normal urothelium and urothelial preneoplastic lesions. The following morphometric parameters were evaluated: nuclear area, nuclear perimeter and maximum nuclear diameter. For the immunohistochemical study we used five lectins, antibodies against four epithelial differentiation antigens, and antibodies against blood group isoantigens. A progressive increase in nuclear size from normal urothelium to dysplastic urothelium and Cis was detected. Nuclear size values in Cis and in high-grade, high-stage bladder carcinomas were similar. The most relevant immunohistochemical results were obtained with CEA, CK, UEA-1 and ABH isoantigens, which show significant immunoreactivity changes in preneoplastic urothelium and Cis when compared with normal urothelium. We conclude that bladder Cis behaves morphometrically and immunohistochemically as an invasive bladder carcinoma, and we emphasize the usefulness of these techniques for detecting flat dysplastic and neoplastic lesions in random bladder biopsies. |
| Databáze: | OpenAIRE |
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