Correlations between vessel stiffness and biomarkers of senescent cell in elderly patients
| Autor: | A. G. Sorokina, A. Yu. Efimenko, O. A. Grigorieva, E. S. Novoseletskaya, N. A. Basalova, N. A. Aleksandrushkina, M. A. Vigovskiy, K. I. Kirillova, I. D. Strazhesko, A. V. Orlov, A. V. Balatskiy, L. М. Samokhodskaya, N. V. Danilova, U. D. Dychkova, A. A. Akopyan, V. V. Kakotkin, D. A. Asratyan, Z. A. Akopyan, Ya. A. Orlova |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Kardiologiia. 62:15-22 |
| ISSN: | 2412-5660 0022-9040 |
| Popis: | Aim To study the association between vascular wall stiffness and known markers for accumulation of senescent cells in blood, cells, and tissues of old patients.Material and methods This study included male and female patients aged 65 years and older who were referred to an elective surgical intervention, that included a surgical incision in the area of the anterior abdominal wall or large joints and met the inclusion and exclusion criteria. For all patients, traditional cardiovascular (CV) risk factors and arterial wall stiffness (pulse wave velocity, PWV) were evaluated. Also, biomaterials (peripheral blood, skin, subcutaneous adipose tissue) were collected during the surgery and were used for isolation of several cell types and subsequent histological analysis to determine various markers of senescent cells.Results The study included 80 patients aged 65 to 90 years. The correlation analysis identified the most significant indexes that reflected the accumulation of senescent cells at the systemic, tissue, and cellular levels (r>0.3, рConclusion Stiffness of great arteries as measured by PWV significantly correlates with a number of plasma, tissue, and cellular markers for accumulation of senescent cells. This fact suggests PWV as a candidate for inclusion in the panel of parameters for evaluation and monitoring of the biological age during the senolytic therapy. |
| Databáze: | OpenAIRE |
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