Height, body mass index, and prostate cancer risk and mortality by way of detection and cancer risk category
| Autor: | Bengt Järvholm, Sylvia H J Jochems, Tanja Stocks, Marju Orho-Melander, Christel Häggström, Pär Stattin, Angela M. Wood |
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| Přispěvatelé: | Jochems, Sylvia HJ [0000-0001-7676-1488], Häggström, Christel [0000-0001-6808-4405], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Poor prognosis body mass index urologic and male genital diseases Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Humans Obesity Risk factor Aged Prostate cancer risk Sweden Cancer och onkologi business.industry Prostatic Neoplasms Middle Aged Overweight medicine.disease Prognosis prostate cancer Body Height observational research 030220 oncology & carcinogenesis Cancer and Oncology Observational study Cancer risk business body size Body mass index height |
| Popis: | Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated height and body mass index (BMI) among 431 902 men in five Swedish cohorts in relation to PCa risk, according to cancer risk category and detection mode, and PCa-specific mortality using Cox regression. Statistical tests were two-sided. Height was positively associated with localised intermediate-risk PCa (HR per 5 cm, 1.03, 95% CI 1.01 to 1.05), while overweight and obesity were negatively associated with localised low- and intermediate-risk PCa (HRs per 5 kg/m2 , 0.86, 95% CI 0.81 to 0.90, and 0.92, 95% CI 0.88 to 0.97). However, these associations were partially driven by PCa's detected by asymptomatic screening and, for height, also by symptoms unrelated to PCa. The HR of localised PCa's, per 5 kg/m2 , was 0.88, 95% CI 0.83 to 0.92 for screen-detected PCa's, and 0.96, 95% CI 0.90 to 1.01 for PCa's detected through lower urinary tract symptoms. BMI was positively associated with PCa-specific mortality in the full population and in case-only analysis of each PCa risk category (HRs per 5 kg/m2 , 95% CI 1.11 to 1.22, P for heterogeneity = 0.14). More active health-seeking behaviour among tall and normal-weight men may partially explain their higher risk of localised PCa. The higher PCa-specific mortality among obese men accros all PCa risk categories in our study suggests obesity as a potential target to improve the prognosis of obese PCa patients. |
| Databáze: | OpenAIRE |
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