Clinical Approach to Mast Cell Activation Syndrome: A Practical Overview
| Autor: | Cristobalina Mayorga, María M. Escribese, Victor Matheu, Marina Perez-Gordo, A Matito, M E Seoane-Reula, Mariona Pascal, O Luengo-Sánchez, Moises Labrador-Horrillo, N Longo |
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| Rok vydání: | 2021 |
| Předmět: |
Mast Cell Activation Syndrome
Immunology Tryptase Mast cell activation syndrome Signs and symptoms 03 medical and health sciences 0302 clinical medicine 0502 economics and business medicine Humans Immunology and Allergy Mast Cells Anaphylaxis biology business.industry Mast cell activation 05 social sciences medicine.disease Mast cell Highly sensitive medicine.anatomical_structure 030228 respiratory system biology.protein Tryptases 050211 marketing Bone marrow Neoplasm Recurrence Local medicine.symptom business Mastocytosis |
| Zdroj: | Journal of Investigational Allergy and Clinical Immunology. 31:461-470 |
| ISSN: | 1018-9068 |
| DOI: | 10.18176/jiaci.0675 |
| Popis: | The diagnosis of mast cell activation syndrome (MCAS) is defined by 3 criteria: (1) typical clinical signs and symptoms of acute, recurrent (episodic), and systemic mast cell activation (MCA); (2) increase in tryptase level to >20% + 2 ng/mL within 1-4 hours after onset of the acute crisis; and (3) response of MCA symptoms to antimediator therapy. Classification of MCAS requires highly sensitive and specific methodological approaches for the assessment of clonal bone marrow mast cells at low frequencies. The Spanish Network on Mastocytosis score has been used successfully as a predictive model for selecting MCAS candidates for bone marrow studies based on a high probability of an underlying clonal mast cell disorder. In this article, we propose a diagnostic algorithm and focus on the practical evaluation and management of patients with suspected MCAS. Key words: Anaphylaxis. Antimediator therapy. Mast cell activation syndrome. Mast cell mediator release–related symptoms. Tryptase. |
| Databáze: | OpenAIRE |
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