Clinical Outcome of Autologous Hematopoietic Stem Cell Infusion via Hepatic Artery or Portal Vein in Patients with End-stage Liver Diseases
| Autor: | Shao-ping Deng, Le Luo, Ping Xie, Lanyun Luo, Haibo Zou, Yutong Yao, Lingling Wei, Tian Zhang, Maozhu Yang, Xiao-bing Huang, Yifan Zhu, Xiaolun Huang, Hua Xue |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroenterology Disease-Free Survival End Stage Liver Disease Liver disease Hepatic Artery Liver Function Tests Internal medicine medicine Humans Infusions Intra-Arterial Autologous transplantation Prospective Studies Infusions Intravenous Prospective cohort study Aged medicine.diagnostic_test Portal Vein business.industry Hematopoietic Stem Cell Transplantation General Medicine Middle Aged medicine.disease Surgery Transplantation Treatment Outcome medicine.anatomical_structure Liver biopsy Female Liver function Liver function tests business Artery |
| Zdroj: | Chinese Medical Sciences Journal. 29:15-22 |
| ISSN: | 1001-9294 |
| DOI: | 10.1016/s1001-9294(14)60018-3 |
| Popis: | To investigate the efficacy of hematopoietic stem cell (HSC) transplantation via the hepatic artery vs. the portal vein for end-stage liver disease (ESLD).Patients with hepatic decompensation were prospectively recruited from September 2010 to September 2012 to receive HSC transplantation via the hepatic artery or the portal vein. Liver function was examined at 3, 6, and 12 months after transplantation. Liver biopsy Results were analyzed using the Knodell score.Eighty patients (58 males and 22 females) were enrolled in the study. The Child-Pugh score was grade B in 69 cases, and grade C in the remaining 11 cases. HSC transplantation was performed via the portal vein in 36 patients and via the hepatic artery in 44 patients. ALT levels decreased while serum albumin levels increased significantly in both groups at 6 and 12 months after HSC transplantation (P0.05 compared with pre-transplantation levels). Total bilirubin levels decreased significantly in both groups at 3, 6, and 12 months after HSC transplantation (P0.05 compared with pre-transplantation levels). Additionally, prothrombin time decreased in both groups at 12 months after HSC transplantation (P0.05 compared with pre-transplantation level). There were no significant differences in ALT, total bilirubin and prothrombin time between the two groups either before or after transplantation. Moreover, Knodell score decreased significantly at 6 and 12 months. Histological examination showed that liver cell edema, degeneration, necrosis, and inflammation were significantly relieved at 3, 6, and 12 months after transplantation. The incidence of portal vein thrombosis, upper gastrointestinal bleeding, and hepatic encephalopathy were 1.25%, 3.75%, and 2.5% respectively. The one-year survival rate was 100%.Autologous HSC transplantation improves liver function and histology in ESLD patients. The administration route of HSC has no significant impact on the efficacy of transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|