Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes

Autor: Małgorzata Myśliwiec, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Piotr Trzonkowski, Bartosz Słomiński
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
endocrine system diseases
Disease
Comorbidity
Systemic inflammation
Gastroenterology
0302 clinical medicine
Diabetes complications
Gene Frequency
Drug Discovery
Genotype
Medicine
Diabetic Nephropathies
Child
Genetics (clinical)
0303 health sciences
Up-Regulation
Type 1 diabetes
Hypertension
Molecular Medicine
Original Article
Female
medicine.symptom
Genetic Markers
medicine.medical_specialty
endocrine system
Adolescent
030209 endocrinology & metabolism
Nephropathy
Autoimmune thyroiditis
03 medical and health sciences
Internal medicine
Humans
Genetic Predisposition to Disease
Allele
Codon
Alleles
030304 developmental biology
Dyslipidemias
Diabetic Retinopathy
Polymorphism
Genetic
business.industry
Thyroiditis
Autoimmune
nutritional and metabolic diseases
medicine.disease
Celiac Disease
TP53 codon 72 polymorphism
Diabetes Mellitus
Type 1
Case-Control Studies
Tumor Suppressor Protein p53
business
Dyslipidemia
Zdroj: Journal of Molecular Medicine (Berlin, Germany)
ISSN: 1432-1440
0946-2716
Popis: Abstract Wild-type TP53 plays an important role in the regulation of immune response and systemic inflammation. In type 1 diabetes (T1D), TP53 pathways are upregulated and an increased susceptibility to apoptosis is observed. We hypothesize that TP53 codon 72 polymorphism could be associated with complications and comorbidities in patients with T1D. We have investigated the associations of the TP53 codon 72 polymorphism with the T1D complications and comorbidities (retinopathy, nephropathy, hypertension, dyslipidemia, autoimmune thyroiditis, and celiac disease) in 350 patients. The key results of our approach are as follows: (1) In diabetic subjects, the Pro/Pro genotype is associated with an increased risk of microvascular complications, dyslipidemia, and celiac disease; (2) the Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease; (3) the Pro allele is associated with an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease. Although further studies are required, our results for the first time indicate that the TP53 codon 72 polymorphism could be considered a genetic marker to predict the increased susceptibility to some T1D complications and comorbidities. Key messages We analyzed the TP53 codon 72 polymorphism in patients with T1D. Pro/Pro genotype is associated with an increased risk of microvascular complications, dyslipidemia, and celiac disease. The Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease. The Pro allele is associated with an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease.
Databáze: OpenAIRE
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