BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells
| Autor: | Bernard P. Mahon, Emer L. Molloy, J. Bernadette Moore, Shirley O'Dea, Laura Madrigal-Estebas, Joanne C. Masterson, Aine Adams |
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| Rok vydání: | 2008 |
| Předmět: |
animal structures
Cell Survival Clinical Biochemistry Morphogenesis Tenascin Bone Morphogenetic Protein 4 Biology Bone morphogenetic protein Models Biological Epithelium Cell Line Adherens junction Mesoderm Endocrinology Cell Movement Humans Institute of Immunology Epithelial–mesenchymal transition Lung Cytoskeleton Epithelial cell differentiation Cell Proliferation Cadherin Epithelial Cells Cell Biology Cadherins Cell biology Gene Expression Regulation Microscopy Fluorescence embryonic structures Mesoderm formation Bone Morphogenetic Proteins biology.protein |
| Zdroj: | Growth factors (Chur, Switzerland). 26(1) |
| ISSN: | 0897-7194 |
| Popis: | Bone morphogenetic proteins (BMPs) are critical morphogens and play key roles in epithelial-mesenchymal transitions (EMTs) during embryogenesis. BMP4 is required for early mesoderm formation and also regulates morphogenesis and epithelial cell differentiation in developing lungs. While, BMP signalling pathways are activated during lung inflammation in adult mice, the role of BMPs in adult lungs remains unclear. We hypothesised that BMPs are involved in remodelling processes in adult lungs and investigated effects of BMP4 on airway epithelial cells. BEAS-2B cell growth decreased in the presence of BMP4. Cells acquired a mesenchymal-like morphology with downregulation of adherens junction proteins and increased cell motility. Changes in extracellular matrix-related gene expression occurred with BMP4 treatment including upregulation of collagens, fibronectin and tenascin C. We conclude that the activity of BMP4 in EMT during development is recapitulated in adult airway epithelial cells and suggest that this activity may contribute to inflammation and fibrosis in vivo. |
| Databáze: | OpenAIRE |
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