The effects of guided discontinuation of antipsychotics on neurocognition in first onset psychosis
| Autor: | Durk Wiersma, G. Faber, A R van Gool, H.G. Smid, R.J. van den Bosch |
|---|---|
| Přispěvatelé: | Science in Healthy Ageing & healthcaRE (SHARE) |
| Rok vydání: | 2010 |
| Předmět: |
Olanzapine
Adult Male medicine.medical_specialty Pediatrics Psychosis HALOPERIDOL Neuropsychological Tests law.invention 03 medical and health sciences 0302 clinical medicine Cognition Randomized controlled trial law SCHIZOPHRENIA RISPERIDONE medicine Antipsychotics DRUGS Humans Attention 1ST-EPISODE PSYCHOSIS 030212 general & internal medicine Longitudinal Studies Psychiatry METAANALYSIS First episode Risperidone MEDICATIONS Guided discontinuation medicine.disease Neurocognitive function 030227 psychiatry Discontinuation Psychiatry and Mental health Memory Short-Term Treatment Outcome Psychotic Disorders COGNITIVE CHANGE Schizophrenia TRIAL Female OLANZAPINE Psychology Neurocognitive medicine.drug Antipsychotic Agents |
| Zdroj: | European Psychiatry, 27(4), 275-280. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| ISSN: | 1778-3585 0924-9338 |
| Popis: | ObjectiveTo assess the effects of second generation antipsychotics on neurocognitive function in patients with stable remission of first episode psychosis.MethodsFifty-three patients with first onset psychosis in the schizophrenia spectrum entered a randomised controlled trial of guided discontinuation (GD) versus maintenance treatment (MT) with second generation antipsychotics. A comprehensive neurocognitive test battery was administered at the time of remission and shortly after dose reduction or discontinuation (GD-group) or at the same time in the MT-group.ResultsWith the exception of negative symptoms, PANSS scores decreased over time and neurocognition improved significantly on most tests in both groups. The GD-group, however, improved significantly more than the MT-group on three neurocognitive measures in the domain of speed of processing.ConclusionThese data suggest that, in first episode patients, dose reduction or discontinuation of second generation antipsychotics after stable remission is achieved, might improve neurocognitive function more than continuing second generation antipsychotics, suggesting a negative role for second generation antipsychotics, specifically in the domain of speed of processing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|