Preparation and characterization of pH sensitive crosslinked Linseed polysaccharides-co-acrylic acid/methacrylic acid hydrogels for controlled delivery of ketoprofen

Autor: Alia Erum, Ume Ruqia Tulain, Faiza Akhter, Farya Shabir, Muhammad Ajaz Hussain, Mahmood Ahmad
Rok vydání: 2017
Předmět:
Ketoprofen
Linum
ketoprofen
Materials science
Polymers and Plastics
General Chemical Engineering
Radical polymerization
macromolecular substances
02 engineering and technology
010402 general chemistry
Polysaccharide
01 natural sciences
Article
chemistry.chemical_compound
parasitic diseases
Polymer chemistry
Materials Chemistry
medicine
drug release
Acrylic acid
chemistry.chemical_classification
biology
technology
industry
and agriculture
General Chemistry
Potassium persulfate
021001 nanoscience & nanotechnology
biology.organism_classification
lcsh:TP1080-1185
0104 chemical sciences
pH responsive
lcsh:Polymers and polymer manufacture
Linseed hydrogel-co-acrylic acid
chemistry
Methacrylic acid
Self-healing hydrogels
hydrogel
0210 nano-technology
Linseed hydrogel-co-methacrylic acid
medicine.drug
Zdroj: Designed Monomers and Polymers
Designed Monomers and Polymers, Vol 20, Iss 1, Pp 485-495 (2017)
ISSN: 1568-5551
Popis: Some pH responsive polymeric matrix of Linseed (Linum usitatissimum), L. hydrogel (LSH) was prepared by free radical polymerization using potassium persulfate (KPS) as an initiator, N,N-methylene bisacrylamide (MBA) as a crosslinker, acrylic acid (AA) and methacrylic acid (MAA) as monomers; while ketoprofen was used as a model drug. Different formulations of LSH-co-AA and LSH-co-MAA were formulated by varying the concentration of crosslinker and monomers. Structures obtained were thoroughly characterized using Fourier transforms infrared (FTIR) spectroscopy, XRD analysis and Scanning electron microscopy. Sol-gel fractions, porosity of the materials and ketoprofen loading capacity were also measured. Swelling and in vitro drug release studies were conducted at simulated gastric fluids, i.e., pH 1.2 and 7.4. FTIR evaluation confirmed successful grafting of AA and MAA to LSH backbone. XRD studies showed retention of crystalline structure of ketoprofen in LSH-co-AA and its amorphous dispersion in LSH-co-MAA. Gel content was increased by increasing MBA and monomer content; whereas porosity of hydrogel was increased by increasing monomer concentration and decreased by increasing MBA content. Swelling of copolymer hydrogels was high at pH 7.4 and low at pH 1.2. Ketoprofen release showed an increasing trend by increasing monomer content; however it was decreased with increasing MBA content. Sustained release of ketoprofen was noted from copolymers and release followed Korsmeyer-Peppas model.
Databáze: OpenAIRE
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