Investigation of mechanical properties of porous composite scaffolds with tailorable degradation kinetics after in vitro degradation using digital image correlation
| Autor: | Tomasz Brynk, Frederik Vanmeert, Arie Bruinink, Jakub Jaroszewicz, Wojciech Święszkowski, Joanna Idaszek |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Digital image correlation
Materials science Polymers and Plastics Simulated body fluid Composite number Modulus 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention chemistry.chemical_compound law Materials Chemistry Composite material Fused deposition modeling Physics technology industry and agriculture General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences PLGA Chemistry chemistry Ceramics and Composites Degradation (geology) 0210 nano-technology Ternary operation |
| Zdroj: | Polymer composites |
| ISSN: | 0272-8397 |
| Popis: | Tissue engineering combines artificial scaffolds and living cells in order to reconstruct damaged tissues and organs. The biodegradable scaffolds should maintain their mechanical properties during first stages of the regeneration. The aim of this study was to investigate the extent the degradation affects the mechanical stability of novel biodegradable composite scaffolds in relation to their composition. The scaffolds were made using fused deposition modeling. They were composed of ternary composites containing poly(e-caprolactone) (PCL), 5 wt% of tricalcium phosphate (TCP) and 5, 15, and 25 wt% of poly(lactide-co-glycolide) (PLGA). Scaffolds made of pristine PCL and binary composite PCL–TCP were tested as reference samples. The degradation experiment was carried out in simulated body fluid at 37°C for 12 weeks. Mechanical tests were carried out in a mechanical tester. Strain was measured using digital image correlation and crossbar displacement. Chemical composition had a significant effect on initial mechanical properties and their changes during degradation. The initial apparent Young's modulus of ternary composite scaffolds was two times higher than that of PCL–TCP. Higher PLGA concentration yielded faster decrease of the mechanical properties. At the end of the experiment, there were no significant differences of the modulus among all tested materials although degradation of the ternary composite scaffolds was significantly advanced. POLYM. COMPOS., 38:2402–2410, 2017. © 2015 Society of Plastics Engineers |
| Databáze: | OpenAIRE |
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