MRI study of regional variations of pharyngeal wall compliance in cats
| Autor: | Susan S. Margulies, Allan I. Pack, Michael J. Brennick, Luke Hiller, Malcolm D. Ogilvie, Warren B. Gefter |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Physiology Respiratory physiology Physiology (medical) Image Processing Computer-Assisted medicine Carnivora Animals Respiratory system Air Pressure medicine.diagnostic_test Palate business.industry Pharynx Magnetic resonance imaging Anatomy medicine.disease Magnetic Resonance Imaging respiratory tract diseases Compliance (physiology) Obstructive sleep apnea Hypopharynx medicine.anatomical_structure Cats Respiratory Mechanics Female Airway business Compliance |
| Zdroj: | Journal of Applied Physiology. 85:1884-1897 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | Upper airway compliance indicates the potential of the airway to collapse and is relevant to the pathogenesis of obstructive sleep apnea. We hypothesized that compliance would vary over the rostral-to-caudal extent of the pharyngeal airway. In a paralyzed isolated upper airway preparation in cats, we controlled static upper airway pressure during magnetic resonance imaging (MRI, 0.391-mm resolution). We measured cross-sectional area and anteroposterior and lateral dimensions from three-dimensional reconstructed MRIs in axial slices orthogonal to the airway centerline. High-retropalatal (HRP), midretropalatal (MRP), and hypopharyngeal (HYP) regions were defined. Regional compliance was significantly increased from rostral to caudal regions as follows: HRP < MRP < HYP ( P < 0.0001), and compliance differences among regions were directly related to collapsibility. Thus our findings in the isolated upper airway of the cat support the hypothesis that regional differences in pharyngeal compliance exist and suggest that baseline regional variations in compliance and collapsibility may be an important factor in the pathogenesis and treatment of obstructive sleep apnea. |
| Databáze: | OpenAIRE |
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