Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells
| Autor: | I.M. Zurina, Nastasia V. Kosheleva, V.S. Repin, A.F. Fidarov, E E Ustinova, I.N. Saburina, T D Kolokol'tsova, A.A. Gorkun |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Stromal cell 0206 medical engineering Cell Culture Techniques Adipose tissue 02 engineering and technology Bone tissue Regenerative medicine General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley 03 medical and health sciences Vasculogenesis Osteogenesis Spheroids Cellular Adipocytes medicine Animals Osteoblasts Chemistry Mesenchymal stem cell Spheroid Cell Differentiation General Medicine 020601 biomedical engineering In vitro Rats Cell biology 030104 developmental biology medicine.anatomical_structure Adipose Tissue |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:163-169 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4306-4 |
| Popis: | Vascularization of bioengineered bone tissue constructs remains a challenging problem of regenerative medicine. Spheroids generated in 3D culture of adipose-derived stromal cells supplemented with inducing factors demonstrate stable characteristics and express of mesenchymal, endothelial, and osteoblasts markers, and represent a prototype of vascularized microtissue. Adipose-derived stromal cells spheroids induced to both angio- and osteogenic differentiation can be used in development of new innovative technologies for in vitro fabrication of vascularized bioequivalents for repair of large bone defects. |
| Databáze: | OpenAIRE |
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