State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials—A Multidisciplinary Approach
| Autor: | Stanley R. Hamilton, Hala R. Makhlouf, Shaheen Islam, William D. Travis, James H. Doroshow, David E. Kleiner, Michael D. Kuo, Elliot Levy, Rebecca A. Enos, Maria Isabel Fiel, Robert D. Suh, Peter Schirmacher, Katherine V. Ferry-Galow, Shannon J. McCall, Alda L. Tam |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Lung Neoplasms Liver tumor Biopsy MEDLINE 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Multidisciplinary approach Internal medicine medicine Humans Clinical Trials as Topic Lung medicine.diagnostic_test business.industry Liver Neoplasms Cancer medicine.disease Molecular biomarkers National Cancer Institute (U.S.) United States Clinical trial Treatment Outcome medicine.anatomical_structure 030220 oncology & carcinogenesis Special Articles business |
| Zdroj: | J Clin Oncol |
| ISSN: | 1527-7755 0732-183X |
| Popis: | PURPOSE National Cancer Institute (NCI)–sponsored clinical trial network studies frequently require biopsy specimens for pharmacodynamic and molecular biomarker analyses, including paired pre- and post-treatment samples. The purpose of this meeting of NCI-sponsored investigators was to identify local institutional standard procedures found to ensure quantitative and qualitative specimen adequacy. METHODS NCI convened a conference on best biopsy practices, focusing on the clinical research community. Topics discussed were (1) criteria for specimen adequacy in the personalized medicine era, (2) team-based approaches to ensure specimen adequacy and quality control, and (3) risk considerations relevant to academic and community practitioners and their patients. RESULTS AND RECOMMENDATIONS Key recommendations from the convened consensus panel included (1) establishment of infrastructure for multidisciplinary biopsy teams with a formalized information capture process, (2) maintenance of standard operating procedures with regular team review, (3) optimization of tissue collection and yield methodology, (4) incorporation of needle aspiration and other newer techniques, and (5) commitment of stakeholders to use of guideline documents to increase awareness of best biopsy practices, with the goal of universally improving tumor biopsy practices. |
| Databáze: | OpenAIRE |
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