Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB

Autor:	Mesude Bicak, Pekka Taimen, Kim Pettersson, Hans Lilja, Robert J. Klein, Xing Wang, Xiaoni Gao, Riina Minna Väänänen, Xing Xu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male RNA Untranslated Genotype Quantitative Trait Loci Single-nucleotide polymorphism Biology medicine.disease_cause Polymorphism Single Nucleotide 03 medical and health sciences Prostate cancer 0302 clinical medicine Cell Line Tumor LNCaP Genetics medicine SNP Humans MSMB Genetic Predisposition to Disease Molecular Biology Genetics (clinical) Alleles 030304 developmental biology Gene Editing 0303 health sciences Colocalization Prostatic Neoplasms Prostatic Secretory Proteins General Medicine medicine.disease Gene Expression Regulation 030220 oncology & carcinogenesis Expression quantitative trait loci Cancer research RNA Long Noncoding General Article CRISPR-Cas Systems Carcinogenesis Genome-Wide Association Study
Zdroj:	Hum Mol Genet
Popis:	How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for SNHG11 (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e63fb7813e07232a486a3f9718a57 https://europepmc.org/articles/PMC7526792/ Zobrazit plný text záznamu