A specific role forPRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice
| Autor: | Fatemeh Montazer-Torbati, Eric Pailhoux, Aurélie Allais-Bonnet, Maëlle Pannetier, Bruno Passet, Johan Castille, Maeva Elzaiat, Marjolaine André, Jean-Luc Vilotte, Katayoun Moazami-Goudarzi |
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| Přispěvatelé: | Biologie du Développement et Reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Allice, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Pailhoux, Eric |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system [SDV]Life Sciences [q-bio] Doppel foetal Leydig goat mouse prion Shadoo Biology General Biochemistry Genetics and Molecular Biology PRNP 03 medical and health sciences Gene expression Gene family [INFO]Computer Science [cs] Prion protein Gene Research Articles urogenital system Cell biology 030104 developmental biology Immunology Development of the gonads Spermatogenesis Research Article |
| Zdroj: | FEBS Open Bio FEBS Open Bio, Wiley Open Access/Elsevier, 2016, 6, pp.4-15. ⟨10.1002/2211-5463.12002⟩ FEBS Open Bio (6), 4-15. (2016) |
| ISSN: | 2211-5463 |
| DOI: | 10.1002/2211-5463.12002 |
| Popis: | International audience; Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of PRNP and SPRN in both species and in both male and female gonads, but with a weaker expression of SPRN. By contrast, expression of PRND was found to be sex-dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that PRND seems to be a key marker of foetal Leydig cells specifically in goats, suggesting a yet unknown role for its encoded protein Doppel during gonadal differentiation in nonrodent mammals. |
| Databáze: | OpenAIRE |
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