Improved n-3 fatty acid status does not modulate insulin resistance in fa/fa Zucker rats
| Autor: | Carla G. Taylor, Peter Zahradka, Melani E. Gillam, Amy Noto |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Adipose Tissue White Health Status Clinical Biochemistry Dietary lipid Adipose tissue Biology Islets of Langerhans Insulin resistance Internal medicine Fatty Acids Omega-3 medicine Animals Body Fat Distribution Obesity Unsaturated fatty acid Cell Size chemistry.chemical_classification Glucose tolerance test medicine.diagnostic_test Insulin Gene Expression Profiling Body Weight Fatty acid Cell Biology Organ Size Glucose Tolerance Test medicine.disease Lipid Metabolism Animal Feed Dietary Fats Rats Rats Zucker Endocrinology chemistry Insulin Resistance Polyunsaturated fatty acid |
| Zdroj: | Prostaglandins, leukotrienes, and essential fatty acids. 81(5-6) |
| ISSN: | 1532-2823 |
| Popis: | The objective was to examine the effect of polyunsaturated fatty acid type (plant vs fish oil-derived n-3, compared to n-6 fatty acids in the presence of constant proportions of saturated, monounsaturated and polyunsaturated fatty acids) on obesity, insulin resistance and tissue fatty acid composition in genetically obese rats. Six-week-old fa/fa and lean Zucker rats were fed with a 10% (w/w) mixed fat diet containing predominantly flax-seed, menhaden or safflower oils for 9 weeks. There was no effect of dietary lipid on obesity, oral glucose tolerance (except t=60 min insulin), pancreatic function or molecular markers related to insulin, glucose and lipid metabolism, despite increased n-3 fatty acids in muscle and adipose tissue. The menhaden oil diet reduced fasting serum free fatty acids in both fa/fa and lean rats. These data suggest that n-3 composition does not alter obesity and insulin resistance in the fa/fa Zucker rat model when dietary lipid classes are balanced. |
| Databáze: | OpenAIRE |
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