Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity
| Autor: | Si-Yang Fan, Wei Zhang, Chun-Zhen Wu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Xanthine Oxidase
Gnaphalium Phytochemicals Flavonoid Quinic Acid 010402 general chemistry 01 natural sciences Gout Suppressants chemistry.chemical_compound Drug Discovery Hydroxybenzoates Xanthine oxidase Nuclear Magnetic Resonance Biomolecular IC50 Flavonoids chemistry.chemical_classification Molecular Structure biology Traditional medicine Plant Extracts 010405 organic chemistry Chemistry Adenine General Medicine Gnaphalium affine Quinic acid Plant Components Aerial biology.organism_classification 0104 chemical sciences Enzyme Activation Caffeoylquinic acid Complementary and alternative medicine Phytochemical Drugs Chinese Herbal |
| Zdroj: | Chinese Journal of Natural Medicines. 16:347-353 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(18)30066-9 |
| Popis: | Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (-) ethyl 1, 4-di-O-caffeoylquinate (1) and (-) methyl 1, 4-di-O-caffeoylquinate (2), together with 35 known compounds (3-37). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC50 11.94 μmol·L-1) and 2 (IC50 15.04 μmol·L-1) showed a good inhibitory activity. The current results supported the medical use of the plant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect