Administration of noradrenaline in the autonomic ganglia modifies the testosterone release from the testis using an ex vivo system
| Autor: | Mabel Fóscolo, Miguel N. Palmada, Juan C. Cavicchia, Alberto Conill, Francisco Capani, Zulema Y. Sosa |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Inferior mesenteric ganglion Time Factors Urology Endocrinology Diabetes and Metabolism Autonomic ganglion Adrenergic beta-Antagonists Biology Testicle In Vitro Techniques Testicular artery Norepinephrine Internal medicine medicine.artery Superior mesenteric ganglion Testis medicine Animals Testosterone Rats Wistar Phentolamine Ganglia Autonomic Adrenergic alpha-Antagonists Vas deferens Propranolol Ganglion Rats medicine.anatomical_structure Endocrinology Reproductive Medicine Peripheral nervous system sense organs |
| Zdroj: | International journal of andrology. 32(4) |
| ISSN: | 1365-2605 |
| Popis: | Summary The male gonad receives nerve fibres from the autonomic ganglionic system. These fibres converge on the testis along two pathways, the superior and the inferior spermatic nerves. The superior spermatic nerve runs from the superior mesenteric ganglion alongside the testicular artery, whereas the inferior spermatic nerve originates in inferior mesenteric ganglion, accompanies the vas deferens and penetrates the inferior pole of the testis. The aim of this work was to evaluate androgen release after the addition of noradrenaline or adrenoreceptor antagonists (propranolol or phentolamine) to the ganglionic compartment. An ex vivo system used in a previous work was incubated in two separate containers, one for the testis and the other for the ganglion. Both organs remain interconnected (as in vivo) by the respective spermatic nerve. When noradrenaline was added to the inferior mesenteric ganglion, testosterone release in the gonad container underwent a progressive and significant increment. Propranolol diminishes and phentolamine increases the androgen release. When using the superior mesenteric ganglion, no changes were observed. These results indicate that the ganglionic stimulation of the autonomic system clearly participates in testosterone release from the testis. This effect depends on the ganglion involved. These results make it evident that not only the classical and well-known hypothalamus–hypophysial axis, but also the peripheral nervous system, via the autonomic ganglia, are directly involved in the endocrine control of the testis. |
| Databáze: | OpenAIRE |
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