Can the ischemia-reperfusion syndrome in transplanted kidneys procured from non–heart-beating donors be influenced by adding selenium into the reperfusion solution? an experimental study
| Autor: | V. Treska, V Kuntscher, J. Kobr, L Trefil, J Molác̆ek, J. Racek |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Antioxidant Swine Urinary system medicine.medical_treatment Organ Preservation Solutions Ischemia Kidney Renal Circulation Selenium chemistry.chemical_compound Malondialdehyde Internal medicine medicine Animals Transplantation Homologous Transplantation business.industry Graft Survival Venous blood medicine.disease Glutathione Kidney Transplantation Heart Arrest Disease Models Animal Endocrinology medicine.anatomical_structure chemistry Reperfusion Injury Cardiology Surgery business Perfusion |
| Zdroj: | Transplantation Proceedings. 35:1584-1586 |
| ISSN: | 0041-1345 |
| Popis: | The ischemic-reperfusion syndrome significantly influences the function of a kidney transplanted from a non-heart-beating donor (NHBD). The animal model of a NHBD was used to monitor the influence of exogenous addition of selenium into the reperfusion solution (HTK, Custodiol) with respect to the formation of free oxygen radicals at 0 to 120 minutes after the NHBD transplantation. This maneuvers produced a statistically significant decrease in malondialdehyde concentration, an indicator of free oxygen radicals in the venous blood of the transplanted kidney. The augmentation of the antioxidative capacity of the preservation solution might be a possible route to improve the function of kidneys transplanted from NHBDs. |
| Databáze: | OpenAIRE |
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