Output-limiting symptoms induced by radiofrequency hyperthermia. Are they predictable?
| Autor: | Masahiko Motegi, Takeo Takahashi, Kyoji Ogoshi, Kiyotaka Osawa, Takayuki Asao, Hiroyuki Kuwano, Atsushi Okazaki, Yoshitaka Andou, Hisanori Shoji, Noriyuki Okonogi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Hyperthermia Cancer Research Pathology medicine.medical_specialty Physiology medicine.medical_treatment Antineoplastic Agents Malignant disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Stable Disease Neoplasms Physiology (medical) medicine Humans Aged Aged 80 and over Chemotherapy business.industry Hyperthermia Treatment Hyperthermia Induced Limiting Middle Aged medicine.disease Radiation therapy 030220 oncology & carcinogenesis Anesthesia Concomitant Female business |
| Zdroj: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 32(2):199-203 |
| ISSN: | 0265-6736 |
| Popis: | During radiofrequency (RF) hyperthermia treatment, hot-spot phenomena may occur and prevent treatment continuation if the output is not lowered. We previously reported a significant correlation between the initial energy output at which output-limiting symptoms occurred and patient status. Patients with a complete clinical response had significantly increased temperature, while some patients with partial clinical response and stable disease had increased temperature, depending on the occurrence of output-limiting symptoms. To predict the initial energy output at which output-limiting symptoms occur, we performed multiple regression analysis with the parameters of patients' physical status.Hyperthermia alone or concomitant with chemotherapy and/or radiotherapy was applied in 62 patients with malignant disease for a total of 310 treatments with a Thermotron RF-8 between December 2011 and April 2014.No output-limiting symptoms were shown in 65.5% of 310 treatments. Pain (29.7%), micturition desire (1.9%), skin discomfort (0.6%), subcutaneous induration (1.6%), cold sensation (0.6%), and nausea (0.3%) were reported in the 310 treatments. A good predictive equation for initial energy output at which output-limiting symptoms occur was determined with two parameters, initial time of an output-limiting symptom onset, and thickness of the fat of the abdominal wall. Multiple regression analysis showed an adjusted R(2 )= 0.99 and variance inflation factor 2.We present a good predictive equation for initial energy output at which output-limiting symptoms occur. It is critical to prevent RF hyperthermia-induced output-limiting symptoms and establish new prevention strategies. |
| Databáze: | OpenAIRE |
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